Elementary Lesions

Architectural distortion

Characteristics

• Destruction of the normal lung architecture and its replacement by fibrotic areas, fibrous scars and honeycombing cysts, sometimes both at the same time

Diagnostic Orientation

• Association of several histological features of architectural distortion

  • honeycombing cysts

  • fibrous scars

  • smooth muscle hyperplasia

• The honeycombing cysts are practically always present and most oftenwith fibrotic areas

• In a few cases, the honeycombing cysts are absent and the fibrotic scars are the only sign of architectural distortion